Clinical Pharmacology Chapter 10 Antiplatelets Drugs Q&A (1 OF 11) Sample Questions

1. The mechanism of action of Acetyl Salicylic Acid (ASA) that results in greater effect as an antiplatelet drug is:
  1. A. Selective COX I inhibition
  2. B. Selective COX II inhibition
  3. C. COX I and COX II inhibition
  4. D. Irreversible acetylation of cyclooxygenase
  5. E. Reversible acetylation of cyclooxygenase
Answer
Ans: D
Tips: ASA is the only drug that irreversibly inhibits the enzyme. This action permits a longer duration of action causing platelet aggregation and acetylation of cyclooxygenase.